Although it is common, if obesity related gut damage may worsen asthma symptoms including fatigue, lung infections and an increased risk of severe asthma attacks, which can be life threatening. How increased gut permeability may affect asthma control has not previously been investigated.
Research analysis on Obesity related Gut Damage may worsen Asthma
According to research that will be presented at the Society for Endocrinology annual meeting in Harrogate, changes in gut function brought on by weight gain are connected to an increase in the severity of asthma.
According to the study, gaining weight is significantly associated with greater levels of inflammation, symptoms of gut permeability, and less effective asthma management.
The stomach is highlighted as a potential additional therapeutic target for improving asthma control in obese patients, in addition to weight loss as a viable treatment option for those with severe asthma symptoms.
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The symptoms of 98 individuals with severe asthma were compared by Cristina Parenti and colleagues at Nottingham Trent University to the link between body weight and gut permeability.
The Asthma Control Questionnaire-6 was used to gather symptom information from patients with lean to obese body mass index (BMI). Lipopolysaccharide binding protein (LPB) and calprotectin levels, as well as indicators of asthma-related inflammation, were assessed in blood tests (granzyme-A, IL-5, IL-6, CCL-4). Significantly greater levels of LBP were present in patients with poorly managed asthma, and these levels rose with increasing body weight. Asthma-related inflammatory markers also increased in correlation with increasing LBP concentrations.
Cristina Parenti, the lead researcher, says "Gut permeability, being overweight, and inadequate asthma management have all been demonstrated to be significantly correlated, especially in obese individuals. This shows that dietary changes to enhance gut barrier function may be a successful, alternative therapeutic goal for asthma patients who are obese or overweight
Source: Endocrine Abstracts
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